Description
PCK1 is a maincontrol point for the regulation of gluconeogenesis. PCK1 plays an importantrole in this process by stimulating hepatic glucose production. Theexpression of PCK1 can be regulated by insulin, glucocorticoids, glucagon,cAMP, and diet. Modulation of the signals governing PCK1 levels presents apotential therapeutic approach to the treatment of Insulin resistance andconsequently obesity